The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis
نویسندگان
چکیده
منابع مشابه
SIVA 1 ( SIVA 1 , Apoptosis - Inducing Factor )
Review on SIVA1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
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Tubular damage by cisplatin leads to acute renal failure, which limits its use in cancer therapy. In tubular cells, a primary target for cisplatin is presumably the genomic DNA. However, the pathway relaying the signals of DNA damage to tubular cell death is unclear. In response to DNA damage, the tumor suppressor gene p53 is induced and is implicated in subsequent DNA repair and cell death by ...
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BACKGROUND AND OBJECTIVES Nephrotoxicity is one of the main side effects of the anticancer drug cisplatin, and one of its main therapeutic limitations. It has been suggested that p53 activation plays important roles in renal cell injury by cisplatin. However, the mechanism of p53 activation by cisplatin is unclear. This study examined whether reactive oxygen species (ROS) production by cisplati...
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ژورنال
عنوان ژورنال: Journal of Carcinogenesis
سال: 2009
ISSN: 1477-3163
DOI: 10.4103/1477-3163.45389